Immunogen sequence: KHSIKLVDDQ MNWCDSAIEY LLDQTDVLVV GVLGLQGTGK SMVMSLLSAN TPEEDQRTYV FRAQSAEMKE RGGNQTSGID FFITQERIVF L
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.
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Protein Aliases: Nonsense-mediated mRNA decay factor SMG9; protein smg-9 homolog
Gene Aliases: C19orf61; F17127_1; HBMS; SMG9
UniProt ID: (Human) Q9H0W8
Entrez Gene ID: (Human) 56006