Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
H00000708-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1F3
Immunogen
C1QBP (NP_001203.1, 173 a.a. approximately 282 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: IKNDDGKKAL VLDCHYPEDE VGQEDEAESD IFSIREVSFQ STGESEWKDT NYTLNTDSLD WALYDHLMDF LADRGVDNTF ADELVELSTA LEHQEYITFL EDLKSFVKSQ
Target Information
Replication Protein A (RPA) (also known as human single-stranded DNA binding protein, or HSSB) is involved in DNA replication, repair, and recombination. RPA from human cells is a stable heterotrimer of 70kDa, 32-34kDa, and 11-14kDa subunits (RPA70, RPA32, and RPA14 respectively). RPA is required for the SV40 large tumor antigen-catalyzed unwinding of SV40 DNA and stimulates DNA polymerase alpha and delta. RPA34 is phosphorylated at the G1/S boundary of the cell cycle or upon exposure of cells to DNA damage-inducing agents including ionizing and UV radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ASF/SF2-associated protein p32; C1q globular domain-binding protein; C1qBP; Complement component 1 Q subcomponent-binding protein, mitochondrial; complement component 1, q subcomponent binding protein; gC1q-R protein; Glycoprotein gC1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p33; RPA; SF2AP32; splicing factor SF2-associated protein
Gene Aliases: C1QBP; gC1Q-R; GC1QBP; gC1qR; HABP1; p32; SF2P32
UniProt ID: (Human) Q07021
Entrez Gene ID: (Human) 708
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
mRNA processing
apoptotic process
immune response
complement activation, classical pathway
blood coagulation, intrinsic pathway
RNA splicing
phosphatidylinositol 3-kinase signaling
viral process
regulation of complement activation
negative regulation of interferon-gamma production
negative regulation of interleukin-12 production
negative regulation of MDA-5 signaling pathway
negative regulation of RIG-I signaling pathway
mature ribosome assembly
positive regulation of apoptotic process
innate immune response
positive regulation of cell adhesion
negative regulation of mRNA splicing, via spliceosome
negative regulation of defense response to virus
positive regulation of protein kinase B signaling
positive regulation of mitochondrial translation
positive regulation of neutrophil chemotaxis
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of trophoblast cell migration
positive regulation of dendritic cell chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support