A suggested positive control for immunohistochemical applications for this product is kidney tissue from patients with streptococcal glomerulonephritis. Strong staining was observed in the glomeruli and in some cases the peritubular capillary (potentially clinically significant).
Mouse anti human C1q antibody, clone 004-43.X (3R9/2), recognizes human complement component 1 q (C1q), a approximately 156 kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system.
C1q is a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1.
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Protein Aliases: complement C1q chain A; complement C1q chain B; Complement C1q subcomponent subunit A; Complement C1q subcomponent subunit B; Complement C1q subcomponent subunit C; complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement component 1, q subcomponent, C chain; complement component 1, q subcomponent, gamma polypeptide; complement component C1q, A chain; complement component C1q, B chain; complement subcomponent C1q chain B
Gene Aliases: C1Q-C; C1QA; C1QB; C1QC; C1QG