MGARP plays a role in the trafficking of mitochondria along microtubules. It regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. It participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. It also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology.
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Protein Aliases: CESP-1; Corneal endothelium-specific protein 1; Hypoxia up-regulated mitochondrial movement regulator protein; Mitochondria-localized glutamic acid-rich protein; Ovary-specific acidic protein; Protein MGARP
Gene Aliases: C4orf49; CESP-1; CESP1; GS3582; HUMMR; MGARP; OSAP
UniProt ID: (Human) Q8TDB4
Entrez Gene ID: (Human) 84709