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Product Details
PA5-65637
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human C7orf60. Recombinant protein control fragment (Product #RP-106306).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2663410
Product Specific Information
Immunogen sequence: QERKLEQEKLS GVVKSVHRRL RKKYREVGDF DKIWREHCED EETLCEYAVA MKNLADNHWA KTCEGEGRIE WCCSVCREYF Q
Highest antigen sequence identity to the following orthologs - mouse 99%, rat 38%.
Target Information
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Probable methyltransferase BMT2 homolog; S-adenosylmethionine sensor upstream of mTORC1; UPF0532 protein C7orf60
Gene Aliases: BMT2; C7orf60; SAMTOR
UniProt ID: (Human) Q1RMZ1
Entrez Gene ID: (Human) 154743
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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