C9orf114 is a protein coding gene. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level.
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Protein Aliases: CENP-32; Centromere protein 32; Kinetochore-associated protein; Putative methyltransferase C9orf114; Putative methyltransferase C9orf114 homolog; SPOUT domain-containing methyltransferase 1; uncharacterized protein C9orf114 homolog
Gene Aliases: 9930028P05; AL033358; C9orf114; CENP-32; D2Wsu81e; HSPC109; SPOUT1
Molecular Function: methyltransferase