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Invitrogen
CAB39 Recombinant Rabbit Monoclonal Antibody (K01_2L61)
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FIGURE: 1 / 3
CAB39 Antibody (MA564012) in IHC (P)
Immunohistochemistry (Paraffin) analysis of CAB39 in paraffin-embedded Human Cholangiocarcinoma. Samples were incubated with CAB39 recombinant monoclonal (Product # MA564012). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Product Details
MA564012
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
K01_2L61
Immunogen
A synthetic peptide of human CAB39/MO25 (aa 323-341).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA
Contains
0.01% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KTYLVKQIRD LKRPAQQEA
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Cynomolgus monkey - 100%.
Target Information
Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium binding protein, 39 kDa; Calcium-binding protein 39; MO25alpha; Protein Mo25; unnamed protein product
Gene Aliases: AA408805; AA960512; C78372; CAB39; CGI-66; MO25; MO25alpha
UniProt ID: (Human) Q9Y376, (Mouse) Q06138
Entrez Gene ID: (Human) 51719, (Rat) 301574, (Mouse) 12283
signal transduction
response to activity
intracellular signal transduction
cellular hypotonic response
response to thyroid hormone
negative regulation of potassium ion transmembrane transport
positive regulation of peptidyl-threonine phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
activation of protein kinase activity
positive regulation of peptidyl-serine phosphorylation
protein heterooligomerization
positive regulation of protein serine/threonine kinase activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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