Invitrogen

CALCRL Recombinant Rabbit Monoclonal Antibody (8H9L8)

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

View all (9) CALCRL antibodies

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Datasheet

Protocols

Questions & Answers

Tech Support

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CALCRL Antibody in Immunohistochemistry (IHC) — Sections of Human Cerebral cortex were dewaxed, microwaved in citric acid and incubated with Anti-CALCRL Recombinant Rabbit Monoclonal Antibody (Product # 703811, 1:500 dilution). Sections were then sequentially treated with biotinylated anti-rabbit IgG and AB solution. Sections were then developed in AEC and lightly counterstained with hematoxylin. Note, strong staining of neurons, nerve fibres, and terminals in the cerebral cortex. Inset, peptide neutralization control.

CALCRL Antibody — Antibody specificity was demonstrated by the detection of differential basal expression of the target owing to their inherent genetic constitution. Strong staining of CALCRL was observed in the neurons (cells stained light and medium red) in comparison to the glial/ satellite cells (small cells stained blue) surrounding the neurons tested in Rat dorsal root ganglia tested using Anti-CALCRL Recombinant Rabbit Monoclonal Antibody (Product # 703811) in Immunohistochemistry. {RE}

Product Details

703811

Applications	Tested Dilution	Publications
Immunohistochemistry (IHC)	1:500	-

Product Specifications
Species Reactivity	Human, Rat
Host/Isotype	Rabbit / IgG
Class	Recombinant Monoclonal
Type	Antibody
Clone	8H9L8
Immunogen	Peptides corresponding to human CALCRL [1) aa23-aa40 2) aa48-aa64] View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Purification	Protein A
Storage buffer	PBS, pH 7.4
Contains	0.09% sodium azide
Storage conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_2848243

Product Specific Information

This antibody is predicted to react with Mouse, Bovine.

Target Information

CRLR is a receptor for calcitonin gene-related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-cell/lung/testis, bome marrow, embryo, lung and synovium libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Calcitonin gene-related peptide type 1 receptor; Calcitonin receptor-like receptor; CGRP receptor; CGRP type 1 receptor; Cgrp1 receptor

Gene Aliases: CALCRL; CGRPR; CLR; CRLR; RATCRLR; RNCLR

UniProt ID: (Human) Q16602, (Rat) Q63118

Entrez Gene ID: (Human) 10203, (Rat) 25029

Molecular Function: transmembrane signal receptor