Invitrogen

CALCRL Recombinant Rabbit Monoclonal Antibody (8H9L8)

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details

View all (9) CALCRL antibodies

Datasheet

Questions & Answers

Datasheet

Questions & Answers

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CALCRL Antibody in Immunohistochemistry (IHC) — Sections of Rat Cerebral cortex were dewaxed, microwaved in citric acid and incubated with Anti-CALCRL Recombinant Rabbit Monoclonal Antibody (Product # 703811, 1:500 dilution). Sections were then sequentially treated with biotinylated anti-rabbit IgG and AB solution. Sections were then developed in AEC and lightly counterstained with hematoxylin. Note, strong staining of neurons, nerve fibres, and terminals in the cerebral cortex. Inset, peptide neutralization control.

CALCRL Antibody in Relative expression — Antibody specificity was demonstrated by the detection of differential basal expression of the target owing to their inherent genetic constitution. Strong staining of CALCRL was observed in the neurons (cells stained light and medium red) in comparison to the glial/ satellite cells (small cells stained blue) surrounding the neurons tested in Rat dorsal root ganglia tested using Anti-CALCRL Recombinant Rabbit Monoclonal Antibody (Product # 703811) in Immunohistochemistry. {RE}

Product Details

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

1:500

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Recombinant Monoclonal

Type

Antibody

Clone

8H9L8

Immunogen

Peptides corresponding to human CALCRL [1) aa23-aa40 2) aa48-aa64]

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2848243

Product Specific Information

This antibody is predicted to react with Mouse, Bovine.

Target Information

CRLR is a receptor for calcitonin gene-related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-cell/lung/testis, bome marrow, embryo, lung and synovium libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Calcitonin gene-related peptide type 1 receptor; Calcitonin receptor-like receptor; CGRP receptor; CGRP type 1 receptor; Cgrp1 receptor

Gene Aliases: CALCRL; CGRPR; CLR; CRLR; RATCRLR; RNCLR

UniProt ID: (Human) Q16602, (Rat) Q63118

Entrez Gene ID: (Human) 10203, (Rat) 25029

Molecular Function: G-protein coupled receptor antibacterial response protein defense/immunity protein receptor