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CAMK2B (CaMKII beta) is a serine/threonine kinase that plays a role in synaptic plasticity, synaptic vesicle mobilization and regulation of gene expression. As a dominant kinase in the central nervous system it may function in long term potentiation and neurotransmitter release. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.
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Protein Aliases: calcium/calmodulin-dependent protein kinase II beta; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II beta subunit; CaM kinase II subunit beta; CaM-kinase II beta chain; caMK-II subunit beta; MGC29528; proline rich calmodulin-dependent protein kinase; β CaMKII; βCaMKII
Gene Aliases: CAM2; CAMK2; CAMK2B; CAMKB
UniProt ID: (Human) Q13554
Entrez Gene ID: (Human) 816
Molecular Function: non-receptor serine/threonine protein kinase