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Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.
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Protein Aliases: Calpain htra-3; Calpain-5; nCL-3; New calpain 3; testis tissue sperm-binding protein Li 91mP
Gene Aliases: ADNIV; CAPN5; HTRA3; nCL-3; NCL3; VRNI
UniProt ID: (Human) O15484
Entrez Gene ID: (Human) 726
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