A suggested positive control is rat brain tissue lysate.
PA5-20516 can be used with blocking peptide PEP-0636.
CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ca++-dependent secretion activator; Ca2+ dependent secretion activator; Ca2+-dependent activator protein; Ca2+-dependent activator protein for secretion; Ca2+-dependent secretion activator; Ca2+-regulated cytoskeletal protein; Ca<2+-dependent activator protein for secretion; Ca<2+>dependent activator protein for secretion; CADPS1, CAPS, CAPS1; Calcium-dependent activator protein for secretion 1; Calcium-dependent secretion activator 1; CAPS-1; rCAPS
Gene Aliases: AU067781; CADPS; CADPS1; CAPS; CAPS1; Caps2; KIAA1121; mKIAA1121; UNC-31
Molecular Function: calcium-binding protein