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|Tested species reactivity||Human, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fusion protein derived from the human CASK/LIN-2 protein. This sequence lies approximately 100 residues COOH-terminal to a putative calmodulin-binding domain and is 100% conserved in human, mouse, and rat CASK proteins.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Calmodulin sensitive kinase (CASK/mLIN-2) is a ~112-kDa member of the membrane associated quanylate kinase (MAGUK) protein family with multiple protein binding domains. These include an N-terminal calmodulin kinase (CaMKII) domain and C-terminal PDZ, SH3-, and quanylate kinase domains. CASK possesses both tyrosine kinase and serine/threonine kinase activity. In addition, CASK can form a heterotrimeric complex with Mint (X11or mLIN-10) and Veli (mLIN-7) proteins which is predicted to participate in plasma membrane receptor localization. CASK is localized to neuronal synapses and also interacts with syndecan and neurexin. The guanylate kinase domain of CASK has been shown to interact with the T-box transcription factor, Tbr-1, as a coactivator to induce transcription of genes that contain T-elements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; hCASK; peripheral plasma membrane protein CASK; protein lin-2 homolog; trinucleotide repeat containing 8
CAGH39; CAMGUK; CMG; FGS4; LIN2; MICPCH; MRXSNA; RP11-540L11.1; TNRC8