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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 198-227 amino acids from the central region of human CATB|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:50|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with non-human primate based on sequence homology.
The protein CATB is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
amyloid precursor protein secretase; APP secretase; APPS; Cathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; Cathepsin B1; CPSB; CTSB; cysteine protease
APPS; CPSB; CTSB