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Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cancer/testis antigen 74; Coiled-coil domain-containing protein 36; CT74; Interactor of HORMAD1 protein 1
Gene Aliases: CCDC36; CT74; IHO1
UniProt ID: (Human) Q8IYA8
Entrez Gene ID: (Human) 339834
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