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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 16 amino acid peptide near the carboxy terminus of human CCL17|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||5 ug/ml|
|Western Blot (WB)||1 - 2 ug/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is rat spleen tissue lysate.
PA5-34515 can be used with blocking peptide PEP-1558.
CCL17, also known as TARC, binds to chemokine receptors CCR4 and CCR8 and plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. CCL17 is secreted from monocyte-derived DCs and endothelial cells and is responsible for selective recruitment and migration of activated Th2 lymphocytes. CCL17 is also required for CCR7 and CXCR4-dependent migration of cutaneous dendritic cells under inflammatory conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
A-152E5.3; ABCD-2; C-C motif chemokine 17; CC chemokine TARC; CCL17; chemokine (C-C motif) ligand 17; Chemokine C-C motif ligand 17; SCYA17; small inducible cytokine subfamily A (Cys-Cys), member 17; small inducible cytokine subfamily A Cys-Cys member 17; small inducible cytokine subfamily A17; small-inducible cytokine A17; T cell-directed CC chemokine; TARC; thymus and activation-regulated chemokine
A-152E5.3; ABCD-2; CCL17; SCYA17; Scya17l; TARC