This antibody detects recombinant mouse (rm)CCL5 direct ELISAs. In sandwich ELISAs, approximately 5% cross-reactivity with rhCCL5 and less than 0.2% cross-reactivity with rhTECK and rhVIC was observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: beta-chemokine RANTES; C-C motif chemokine 5; D17S136E; eoCP; eosinophil chemotactic cytokine; MGC17164; MuRantes; SCYA5; SIS-delta; SISd; small inducible cytokine A5; Small-inducible cytokine A5; t cell-specific protein P228; T-cell specific protein p288; T-cell-specific protein RANTES
Gene Aliases: Ccl5; MuRantes; RANTES; Scya5; SISd; TCP228
UniProt ID: (Mouse) P30882
Entrez Gene ID: (Mouse) 20304