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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to human CCR1.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||5-10 µl/test|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Suggested positive control: A375, antigen standard for CCR1 (transient overexpression lysate).
Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CD191; chemokine (C-C motif) receptor 1; chemokine (C-C) receptor 1; CKR-1; CKR1; CMKBR1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1 alpha R; MIP-1 alphaR; MIP-1alpha-R; MIP1aR; RANTES receptor; RANTES-R; SCYAR1
CCR1; CD191; CKR-1; CKR1; CMKBR1; CMKR1; HM145; Mip-1a-R; MIP1aR; SCYAR1