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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Human CCR5 transfected NSO mouse myeloma cells.|
|Storage buffer||PBS with 5% trehalose|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||5-10 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
MA1-24666 detects CCR5 from human samples. This antibody does not detect CCR5 on unfixed human PBMCs. The antibody shows no cross reactivity with CCR1, CCR2 or CCR3.
MA1-24666 has been successfully used in immunohistochemistry and flow cytometry procedures.
The MA1-24666 immunogen is human CCR5 transfected NSO mouse myeloma cells.
Endotoxin level is less than 0.1 EU as determined by the LAL method.
Chemokines have been sub-divided into families on the basis of the relative position of their cysteine residues. The alpha and beta families, with four cysteine residues, are the largest and best characterized. In the alpha family, one amino acid separates the first two cysteine residues (CXC); in the beta family the two cysteine residues (CC) are adjacent to each other.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
HIV-specific cytotoxic T lymphocytes traffic to lymph nodes and localize at sites of HIV replication and cell death.
MA1-24666 was used in immunohistochemistry to investigate the migration of cytotoxic T lymphocytes targeting HIV in vivo
|Brodie SJ,Patterson BK,Lewinsohn DA,Diem K,Spach D,Greenberg PD,Riddell SR,Corey L||The Journal of clinical investigation (105:1407)||2000|
C-C chemokine receptor type 5; C-C CKR-5; C-C motif chemokine receptor 5 A159A; CC-CKR-5; CD195; CD195 antigen; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; CHEMR13; CMKBR5; HIV-1 fusion coreceptor
CC-CKR-5; CCCKR5; CCR-5; CCR5; CD195; CKR-5; CKR5; CMKBR5; IDDM22