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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide, KLH conjugated, corresponding to the C-terminal domain of human CCR7.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-23577 detects CCR7 in human samples.
PA1-23577 has been successfully used in immunohistochemistry (paraffin) procedures.
The PA1-23577 immunogen is a synthetic peptide, KLH conjugated, corresponding to the C-terminal domain of human CCR7.
CCR7, a Chemokine Receptor, is involved in lymphocyte recirculation through secondary lymphoid organs and moving lymphocytes and dendritic cells into distinct tissue compartments. CCR7 is called the Epstein-Barr-induced receptor because it mediates Epstein-Barr viral effects on B lymphocytes. CCR7 expression is up-regulated in mature dendritic cells, B cells infected with EBV, and in CD4+ cells infected with human herpes virus 6 and 7. Immature dendritic cells have been shown to express chemokine receptor 5 (CCR5) and migrate in response to macrophage inflammatory protein-1alpha (MIP-1alpha), whereas mature dendritic cells switch to CCR7 expression and respond exclusively to MIP-3beta and 6Ckine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
C-C chemokine receptor type 7; C-C CKR-7; CC chemokine receptor 7; CC-CKR-7; CCR-7; chemokine (C-C) receptor 7; CMKBR7; EBI1; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced G-protein coupled receptor; Epstein-Barr virus induced gene 1; epstein-Barr virus-induced G-protein coupled receptor 1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor
BLR2; CD197; CDw197; CMKBR7; EBI1