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Staining of C57BL/6 splenocytes with Anti-Mouse CD3e FITC and 1.0 ug of Rat IgG2a K Isotype Control PE-Cyanine7 (top) or 1.0 ug of Anti-Mouse CD197 (CCR7) PE-Cyanine7 (bottom, A18394). Cells were stained at 37°C for 30 minutes. Total viable cells were used for analysis.
|Tested species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a, kappa|
|Immunogen||Prokaryotic recombinant protein corresponding to the external domain of the CD4 molecule/Mouse myeloma.|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CCR7 is a member of the G protein coupled receptor family (subfamily: chemokine). This receptor was identified as a gene induced by the Epstein Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine. It is particularly expressed in lymphoid tissues and in activated B and T lymphocytes and has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Ebi1h, CCR-7, Cdw197, CD197, Cmkbr7, EBI1, CC-CKR-7
C-C chemokine receptor type 7, EBV-induced G-protein coupled receptor 1, MIP-3 beta receptor, chemokine (C-C) receptor 7, epstein-Barr virus-induced G-protein coupled receptor 1, CMKBR7, EBI1, C-C CKR-7, CC chemokine receptor 7, CC-CKR-7