Staining of BALB/c thymocytes with Anti-Mouse CD4 eFluor® 450 (A18371), Anti-Mouse CD8a APC and 0.25 ug of Mouse IgG2a K Isotype Control PE (top) or 0.25 ug of Anti-Mouse CD199 (CCR9) PE (bottom, A18371). Samples were gated on CD4 single positive (orange histogram) or CD4+CD8+ double positive cells (purple histogram).
|Tested species reactivity||Mouse|
|Host / Isotype||Mouse / IgG2a|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.
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