Histogram overlay of human leukocytes labeled with CD10 Mouse Anti-Human (clone MEM-78) Qdot® 705 Conjugate. The black line represents cells from the granulocyte gate and the grey line represents cells from the lymphocyte gate. Sample was acquired and analyzed using 405 nm excitation and a 695/40 band pass emission filter using the Attune(R) Acoustic Cytometer Blue/Violet option (Life Technologies, Carlsbad CA).
|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Storage buffer||0.05M borate, pH 8.3, with 1M betaine|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD10 (neutral endopeptidase - NEP, common acute lymphocytic leukemia antigen - CALLA, membrane metallo-endopeptidase - MME, enkefalinase) is a 100-kDa cell surface zinc metalloprotease cleaving peptide bonds on the N-terminus of hydrophobic amino acids and inactivating multiple physiologically active peptids. CD10 is expressed on various normal cell types, including lymphoid precursor cells, germinal center B lymhocytes, and some epithelial cells, and its expression level serves as a marker for diagnostics of many carcinomas. CD10 is also a differentiation antigen for early B-lymphoid progenitors in the B-cell differentiation pathway and has a key role in regulation of growth, differentiation and signal transduction of many cellular systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.