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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Pre-B cell line NALM-6.|
|Storage buffer||PBS with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 2 publications below|
CD10 (neutral endopeptidase - NEP, common acute lymphocytic leukemia antigen - CALLA, membrane metallo-endopeptidase - MME, enkefalinase) is a 100-kDa cell surface zinc metalloprotease cleaving peptide bonds on the N-terminus of hydrophobic amino acids and inactivating multiple physiologically active peptids. CD10 is expressed on various normal cell types, including lymphoid precursor cells, germinal center B lymhocytes, and some epithelial cells, and its expression level serves as a marker for diagnostics of many carcinomas. CD10 is also a differentiation antigen for early B-lymphoid progenitors in the B-cell differentiation pathway and has a key role in regulation of growth, differentiation and signal transduction of many cellular systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
B-cell reconstitution after lentiviral vector-mediated gene therapy in patients with Wiskott-Aldrich syndrome.
MA1-19558 was used in flow cytometry to discuss the use of stem cells to treat Wiskott-Aldrich syndrome.
|Castiello MC,Scaramuzza S,Pala F,Ferrua F,Uva P,Brigida I,Sereni L,van der Burg M,Ottaviano G,Albert MH,Grazia Roncarolo M,Naldini L,Aiuti A,Villa A,Bosticardo M||The Journal of allergy and clinical immunology (136:692)||2015|
Graft source determines human hematopoietic progenitor distribution pattern within the CD34(+) compartment.
MA1-19558 was used in flow cytometry to characterize the cells in the CD34(+) compartment of grafts
|Arber C,Halter J,Stern M,Rovó A,Gratwohl A,Tichelli A||Bone marrow transplantation (46:650)||2011|
Atriopeptidase; CALLA; CD10; Common acute lymphocytic leukemia antigen; Enkephalinase; membrane metallo-endopeptidase; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase neutral endopeptidase; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; NEP; Neprilysin; neprilysin-390; neprilysin-411; Neutral endopeptidase 24.11; SFE; Skin fibroblast elastase
CALLA; CD10; CMT2T; EPN; MME; NEP; SFE