MA5-17104 targets ITGB4 in FACS, IHC and WB applications and shows reactivity with Human samples.
The MA5-17104 immunogen is purified recombinant fragment of human ITGB4 (amino acids: 1619-1822) expressed in E. Coli.
MA5-17104 detects ITGB4 which has a predicted molecular weight of approximately 202kDa.
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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Protein Aliases: CD104; CD104 antigen; GP150; Integrin beta-4; integrin beta-4 subunit; ITGB4
Gene Aliases: CD104; GP150; ITGB4
UniProt ID: (Human) Q9UIQ4
Entrez Gene ID: (Human) 3691