This Antibody was verified by IP Mass Spectrometry to ensure that the antibody binds to the antigen stated. View Details
MA5-11854 targets CD105 in FACS, IF, IHC (P), and WB applications and shows reactivity with Human and Bovine samples.
The MA5-11854 immunogen is purified GP160 from cell membrane glycoproteins of fresh non-T/non-B acute lymphoblastic leukemia cells.
MA5-11854 was used in the immunofluorescence analysis to successfully detect CD105 in human mesenchymal stem cells derived from iPSCs.
CD105 or Endoglin or GP160 is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists as an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. CD105 binds to TGF-Beta1 and Beta3 with high affinity but not TGF-Beta2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD105; CD105 antigen; END; Endoglin; endoglin (Osler-Rendu-Weber syndrome 1); ENG; HHT1; ORW; ORW1
Gene Aliases: BOS_12128; END; ENG; HHT1; ORW1
UniProt ID: (Human) P17813