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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Human CD123 (IL-3R-alpha) transfected COS cells.|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
IL-3Ra (Interleukin-3 receptor subunit alpha) belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit. It is responsible for the transmission of signal of Interleukin-3. IL-3Ra and IL-3Rb chain heterodimerization is induced by Interleukin-3, which is required for receptor activation but not high affinity binding. It is also reported that IL-3Ra subunits are overexpressed on acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells and are thus potential targets for novel therapeutic agents.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD123 antigen, IL-3 receptor alpha SP2 isoform, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, interleukin 3 receptor, alpha (low affinity), CD123, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, interleukin-3 receptor subunit alpha
IL3R, IL3RAY, CD123, IL3RX, hIL-3Ra, IL3RY
Protein metabolism and modification Protein modification Protein phosphorylation Phosphate metabolism Other metabolism Signal transduction Cell surface receptor mediated signal transduction Other receptor mediated signaling pathway Cell communication Developmental processes