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|Tested species reactivity||Rat|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Phytohaemagglutinin-activated rat lymph node cells|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.2 ug/10^6 cells|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17498 targets CD134/OX-40 in FACS and IHC (F) applications and shows reactivity with Rat samples.
The MA5-17498 immunogen is phytohaemagglutinin-activated rat lymph node cells.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
cluster designation 134; MRC OX40; OX40 antigen; OX40L receptor; Tax-transcriptionally activated glycoprotein 1; TNFRSF4; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor receptor superfamily member 4; tumor necrosis factor superfamily, member 4
Ox40; Tnfrsf4; Txgp1; Txgp1l