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|Tested species reactivity||Human|
|Host / Isotype||Chicken / IgY|
|Immunogen||Amino acids 40-230 of Human CD14.|
|Purification||Antigen affinity chromatography|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1/500-1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-20845 detects CD14 in Human samples.
PA1-20845 has been successfully used in Western Blot procedures.
PA1-20845 immunogen corresponds to Amino acids 40-230 of Human CD14..
CD14 is a single-copy gene encoding 2 protein forms: a 50- to 55-kD glycosylphosphatidylinositol-anchored membrane protein (mCD14) and a monocyte or liver-derived soluble serum protein (sCD14) that lacks the anchor. Both molecules are critical for lipopolysaccharide (LPS)-dependent signal transduction, and sCD14 confers LPS sensitivity to cells lacking mCD14. Increased sCD14 levels are associated with inflammatory infectious diseases and high mortality in gram-negative shock.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein