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|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||2-10 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Cell-surface MMP-9 regulates the invasive capacity of leukemia blast cells with monocytic features.
MA1-19240 was used in flow cytometry to study the role of cell surface MMP-9 in regulating the invasive capacity of leukemia blast cells
|Paupert J,Mansat-De Mas V,Demur C,Salles B,Muller C||Cell cycle (Georgetown, Tex.) (7:1047)||2008|
|Not Applicable||Not Cited||
Filarial antigens impair the function of human dendritic cells during differentiation.
MA1-19240 was used in flow cytometry to assess the effect of microfilariae antigen on dendritic cells
|Semnani RT,Sabzevari H,Iyer R,Nutman TB||Infection and immunity (69:5813)||2001|
Immortalization of human urethral epithelial cells: a model for the study of the pathogenesis of and the inflammatory cytokine response to Neisseria gonorrhoeae infection.
MA1-19240 was used in immunocytochemistry to develop an immortalized human urethral epithelial cell line to study the pathogenesis Neisseria gonorrhoeae infection
|Harvey HA,Post DM,Apicella MA||Infection and immunity (70:5808)||2002|
Maturation of human dendritic cells as sulfasalazine target.
MA1-19240 was used in flow cytometry to examine the effects of sulfasalazine and its metabolites on human dendritic cells.
|Matasi¿ R,Dietz AB,Vuk-Pavlovi¿ S||Croatian medical journal (42:440)||2001|
Cyclooxygenase-independent inhibition of dendritic cell maturation by aspirin.
MA1-19240 was used in flow cytometry to elucidate how aspirin inhibits dendritic cell function.
|Matasic R,Dietz AB,Vuk-Pavlovic S||Immunology (101:53)||2000|
Interferon-alpha and -beta inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14(+) precursors.
MA1-19240 was used in flow cytometry to test if type-I interferons influence dendritic cell differentiation and function.
|McRae BL,Nagai T,Semnani RT,van Seventer JM,van Seventer GA||Blood (96:210)||2000|
CD14; Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein