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Histogram overlay plot of lysed whole blood labeled with CD14 Mouse Anti- Human mAb (cloneTüK4) Qdot® 705 Conjugate. The black line represents gated monocytes and the gray line represents gated lymphocytes. Samples were acquired and analyzed using 405 nm excitation and a 695/40 band pass emission filter using the Attune® Acoustic Cytometer Blue/Violet option (Life Technologies, Carlsbad CA).
|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Tthe CD14 antigen|
|Storage buffer||0.05M borate, pH 8.3, with 1M betaine|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein