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|Tested species reactivity||Human|
|Published species reactivity||Human, Rhesus monkey|
|Host / Isotype||Mouse / IgG2a|
|Storage buffer||PBS with 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 3 publications below|
Commonly used, FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.
CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.
Analyte Specific Reagent
Flow cytometry in the bone marrow staging of mature B-cell neoplasms.
MHCD1401-4 was used in flow cytometry to ask if flow cytometry can be used for the detection of bone marrow involvement in the different types of B-cell malignant neoplasms.
|Stacchini A,Demurtas A,Godio L,Martini G,Antinoro V,Palestro G||Cytometry. Part B, Clinical cytometry (54:10)||2003|
Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction.
MHCD1401-4 was used in flow cytometry to determine of proinflammatory cytokine responses induced by certain bacterial protein adhesins are dependent on TLRs.
|Hajishengallis G,Martin M,Sojar HT,Sharma A,Schifferle RE,DeNardin E,Russell MW,Genco RJ||Clinical and diagnostic laboratory immunology (9:403)||2002|
|Rhesus monkey||Not Cited||
Cytokine expression, natural killer cell activation, and phenotypic changes in lymphoid cells from rhesus macaques during acute infection with pathogenic simian immunodeficiency virus.
MHCD1401-4 was used in flow cytometry to examine the innate and adaptive immune responses of rhesus macaques infected with SIVmac251.
|Giavedoni LD,Velasquillo MC,Parodi LM,Hubbard GB,Hodara VL||Journal of virology (74:1648)||2000|
CD14; Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein