|Tested species reactivity||Mouse|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rat / IgG2a|
|Storage buffer||PBS, pH 7.2, with 0.1% gelatin|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1 µg/test|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
Description: This TX56 monoclonal antibody reacts with mouse CD155 (also known as poliovirus receptor or PVR), a member of the Ig superfamily of nectins and nectin-like proteins. CD155 is expressed on thymocytes (e.g. CD4+CD8+ and CD4+ cells), peripheral T and B lymphocytes (e.g. regulatory T cells, activated T cells, marginal zone B cells, and plasma cells), natural killer (NK) cells, dendritic cells (e.g. mature and activated), and monocytes. CD155 interacts with other nectins, including Nectin-3 and the extraceullar matrix protein vitronectin, the adhesion molecule CD226/DNAM-1, and the NK cell receptor CD96. CD155 plays a role in cell-cell adhesion, including formation of adherens junctions, cell migration, polarization, and NK-mediated cytotoxicity. In humans, but not in mice, CD155 is the receptor for poliovirus.
Applications Reported: This TX56 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This TX56 antibody has been tested by flow cytometric analysis on mouse thymocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens.||Maier MK,Seth S,Czeloth N,Qiu Q,Ravens I,Kremmer E,Ebel M,Müller W,Pabst O,Förster R,Bernhardt G||European journal of immunology (37:2214)||2007|