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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 83 and 342 of Human KIR3DL1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-28393 targets CD158e in WB applications and shows reactivity with Human samples.
The PA5-28393 immunogen is recombinant protein fragment corresponding to a region within amino acids 83 and 342 of Human KIR3DL1.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD158 antigen-like family member E; CD158E1; HLA-BW4-specific inhibitory NK cell receptor; killer cell immunoglobulin-like receptor three domains long cytoplasmic tail 2; killer cell immunoglobulin-like receptor three domains short cytoplasmic tail 1; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1; killer Ig receptor; KIR; KIR antigen 3DL1; KIR3DL1; MHC class I NK cell receptor; natural killer-associated transcript 3; NK-receptor; NKAT3; NKB1; NKB1B; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clones CL-2/CL-11; p70 NK receptor CL-2/CL-11
CD158E; CD158E1; KIR; KIR3DL1; KIR3DL1/S1; KIR3DL2; NKAT-3; NKAT3; NKB1; NKB1B