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|Tested species reactivity||Human, Non-human primate|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||6 ug/ml|
|Functional Assay (FN)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Case study interpretation: Report from the ICCS Annual Meeting, Seattle, 2014.
MA1-10112 was used in flow cytometry to discuss how to diagnosis hematolymphoid neoplasms using flow cytometry.
|Fromm JR,Tagliente DJ,Shaver AC,Neppalli V,Craig FE||Cytometry. Part B, Clinical cytometry (88:413)||2015|
Flow cytometry significantly improves the diagnostic value of fine needle aspiration cytology of lymphoproliferative lesions of salivary glands.
MA1-10112 was used in flow cytometry to compare fine needle aspiration cytology with flow cytometry immunophenotyping for the diagnosis of lymphoproliferative processes in the salivary glands.
|Stacchini A,Aliberti S,Pacchioni D,Demurtas A,Isolato G,Gazzera C,Veltri A,Maletta F,Molinaro L,Novero D||Cytopathology : official journal of the British Society for Clinical Cytology (25:231)||2014|
Transient decrease in human peripheral blood myeloid dendritic cells following influenza vaccination correlates with induction of serum antibody.
MA1-10112 was used in flow cytometry to examine various DC after flu vaccination
|Kobie JJ,Treanor JJ,Ritchlin CT||Immunological investigations (43:606)||2014|
Accurate quantitation of D+ fetomaternal hemorrhage by flow cytometry using a novel reagent to eliminate granulocytes from analysis.
MA1-10112 was used in flow cytometry to discuss methods to detect fetomaternal hemorrhage.
|Kumpel B,Hazell M,Guest A,Dixey J,Mushens R,Bishop D,Wreford-Bush T,Lee E||Transfusion (54:1305)||2014|
Perturbations in eosinophil homeostasis following treatment of lymphatic filariasis.
MA1-10112 was used in flow cytometry to study perturbations in eosinophil homeostasis following treatment of lymphatic filariasis.
|Gopinath R,Hanna LE,Kumaraswami V,Perumal V,Kavitha V,Vijayasekaran V,Nutman TB||Infection and immunity (68:93)||2000|
Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.
MA1-10112 was used in flow cytometry and immunoprecipitation to compare Fc gamma RIII(CD16) transcripts isolated from PMN and NK cells.
|Ravetch JV,Perussia B||The Journal of experimental medicine (170:481)||1989|
Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.
MA1-10112 was used in immunoprecipitation to identify a locus for at least two Fc gamma R genes on human chromosome 1.
|Peltz GA,Grundy HO,Lebo RV,Yssel H,Barsh GS,Moore KW||Proceedings of the National Academy of Sciences of the United States of America (86:1013)||1989|
CD16A; CD16a antigen; CD16B; Fc fragment of IgG low affinity IIIa receptor; Fc fragment of IgG, low affinity III, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc gamma Receptor 3; Fc gamma Receptor III; Fc gamma receptor III-A; Fc gamma receptor IIIa; Fc gamma receptor IIIb; Fc-gamma receptor III-2 (CD 16); Fc-gamma receptor IIIb (CD 16); Fc-gamma receptor IIIb (CD16); fc-gamma RIII; Fc-gamma RIII-alpha; fc-gamma RIII-beta; Fc-gamma RIIIa; fc-gamma RIIIb; FcgammaRIIIA; FCGR3; FCGR3A; FCGR3B; FCGRIII; FCR-10; FCRIII; FCRIIIA; igG Fc receptor III-1; igG Fc receptor III-2; immunoglobulin G Fc receptor III; neutrophil-specific antigen NA; RP11-5K23.1
CD16; CD16A; CD16B; FCG3; FCGR3; FCGR3A; FCGR3B; FCGRIII; FCR-10; FCRIII; FCRIIIA; FCRIIIb; IGFR3; IMD20