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|Tested species reactivity||Human|
|Published species reactivity||Primate, Human, Rhesus monkey|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant protein encoding of domains 1-4 of the N-terminal region of human CD163|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:25-1:50|
|Western Blot (WB)||1:1-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11458 targets CD163 in WB and IHC (P) applications and shows reactivity with Human samples.
The MA5-11458 immunogen is recombinant protein encoding of domains 1-4 of the N-terminal region of human CD163.
CD163 antigen is a type I membrane protein also known as M130 antigen, Ber-Mac3, Ki-M8 or SM4. CD163 is restricted in its expression to the monocytic/macrophage lineage. It is present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells and Langerhan's cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Rapid reconstitution of functionally active 6-sulfoLacNAc(+) dendritic cells (slanDCs) of donor origin following allogeneic haematopoietic stem cell transplant.
MA5-11458 was used in western blot to study the reconstitution and function of donor slan-dendritic cells following allogeneic hematopoietic stem cell transplantation
|Mimiola E,Marini O,Perbellini O,Micheletti A,Vermi W,Lonardi S,Costantini C,Meneghelli E,Andreini A,Bonetto C,Vassanelli A,Cantini M,Zoratti E,Massi D,Zamo' A,Leso A,Quaresmini G,Benedetti F,Pizzolo G,Cassatella MA,Tecchio C||Clinical and experimental immunology (178:129)||2014|
Occurrence of nodular lymphocyte-predominant hodgkin lymphoma in hermansky-pudlak type 2 syndrome is associated to natural killer and natural killer T cell defects.
MA5-11458 was used in immunohistochemistry to study factors associated with nodular lymphocyte-predominant hodgkin lymphoma in hermansky-pudlak type 2 syndrome
|Lorenzi L,Tabellini G,Vermi W,Moratto D,Porta F,Notarangelo LD,Patrizi O,Sozzani S,de Saint Basile G,Latour S,Pace D,Lonardi S,Facchetti F,Badolato R,Parolini S||PloS one (8:null)||2013|
Clinical significance of sIL-2R levels in B-cell lymphomas.
MA5-11458 was used in immunohistochemistry to study the clinical value of soluble IL-2 receptor levels in B-cell lymphomas
|Yoshida N,Oda M,Kuroda Y,Katayama Y,Okikawa Y,Masunari T,Fujiwara M,Nishisaka T,Sasaki N,Sadahira Y,Mihara K,Asaoku H,Matsui H,Seto M,Kimura A,Arihiro K,Sakai A||PloS one (8:null)||2013|
Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: an Italian multicenter study.
MA5-11458 was used in immunohistochemistry to evaluate 43 cases of blastic plasmacytoid dendritic cell neoplasm with leukemic presentation
|Pagano L,Valentini CG,Pulsoni A,Fisogni S,Carluccio P,Mannelli F,Lunghi M,Pica G,Onida F,Cattaneo C,Piccaluga PP,Di Bona E,Todisco E,Musto P,Spadea A,D'Arco A,Pileri S,Leone G,Amadori S,Facchetti F||Haematologica (98:239)||2013|
Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches.
MA5-11458 was used in immunohistochemistry to study the classification of malignant fibrous histiocytoma and fibrosarcoma of bone
|Romeo S,Bovée JV,Kroon HM,Tirabosco R,Natali C,Zanatta L,Sciot R,Mertens F,Athanasou N,Alberghini M,Szuhai K,Hogendoorn PC,Dei Tos AP||Virchows Archiv : an international journal of pathology (461:561)||2012|
Alternative activation of macrophages in rhesus macaques (Macaca mulatta) with endometriosis.
MA5-11458 was used in immunohistochemistry to investigate rhesus macaque macrophage activation during endometriosis
|Smith KA,Pearson CB,Hachey AM,Xia DL,Wachtman LM||Comparative medicine (62:303)||2012|
Intravascular large B-cell lymphoma with hemophagocytic syndrome (Asian variant) in a Caucasian patient.
MA5-11458 was used in immunohistochemistry to report on a case of intravascular large B-cell lymphoma with hemophagocytic syndrome (Asian variant) in a Caucasian patient
|Fung KM,Chakrabarty JH,Kern WF,Magharyous H,Gehrs BC,Li S||International journal of clinical and experimental pathology (5:448)||2012|
Immunophenotypic alterations in resident immune cells and myocardial fibrosis in the aging rhesus macaque (Macaca mulatta) heart.
MA5-11458 was used in immunohistochemistry to study changes in immune cell immunophenotype with myocardial fibrosis in the aging rhesus macaque heart
|Macri SC,Bailey CC,de Oca NM,Silva NA,Rosene DL,Mansfield KG,Miller AD||Toxicologic pathology (40:637)||2012|
Use of classic and novel immunohistochemical markers in the diagnosis of cutaneous myeloid sarcoma.
MA5-11458 was used in immunohistochemistry to study the use of classic and novel immunohistochemical markers in the diagnosis of cutaneous myeloid sarcoma
|Amador-Ortiz C,Hurley MY,Ghahramani GK,Frisch S,Klco JM,Lind AC,Nguyen TT,Hassan A,Kreisel FH,Frater JL||Journal of cutaneous pathology (38:945)||2011|
Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma.
MA5-11458 was used in immunohistochemistry to identify the lymphomagenesis-promoting cytokine
|Munari F,Lonardi S,Cassatella MA,Doglioni C,Cangi MG,Amedei A,Facchetti F,Eishi Y,Rugge M,Fassan M,de Bernard M,D'Elios MM,Vermi W||Blood (117:6612)||2011|
Cellular neurothekeoma with fascicular growth features mimicking cellular dermatofibroma.
MA5-11458 was used in immunohistochemistry to characterize and compare cellular neurothekeoma and dermatofibroma
|Thakral B,Gleason BC,Thomas AB,Billings SD,Victor TA,Cibull TL||The American Journal of dermatopathology (33:281)||2011|
Extraintestinal Crohn's disease mimicking autoimmune inner ear disease: a histopathological approach.
MA5-11458 was used in immunohistochemistry to study the histopathology of a patient with extraintestinal Crohn's disease mimicking autoimmune inner ear disease
|Dettmer M,Hegemann I,Hegemann SC||Audiology & neuro-otology (16:36)||2010|
Synovial immunopathology in haemochromatosis arthropathy.
MA5-11458 was used in immunohistochemistry to investigate the pathophysiology of musculoskeletal tissues in haemochromatosis arthropathy
|Heiland GR,Aigner E,Dallos T,Sahinbegovic E,Krenn V,Thaler C,Weiss G,Distler JH,Datz C,Schett G,Zwerina J||Annals of the rheumatic diseases (69:1214)||2010|
Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells.
MA5-11458 was used in immunohistochemistry to study the presence of dendritic cells expressing autoimmune regulator in peripheral lymphoid tissue in humans
|Poliani PL,Kisand K,Marrella V,Ravanini M,Notarangelo LD,Villa A,Peterson P,Facchetti F||The American journal of pathology (176:1104)||2010|
Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa.
MA5-11458 was used in immunohistochemistry to investigate the pathogenesis of chronic graft-versus-host disease
|Imanguli MM,Swaim WD,League SC,Gress RE,Pavletic SZ,Hakim FT||Blood (113:3620)||2009|
Increased number of islet-associated macrophages in type 2 diabetes.
MA5-11458 was used in immunohistochemistry to examine the status of islet-associated macrophages in type 2 diabetes
|Ehses JA,Perren A,Eppler E,Ribaux P,Pospisilik JA,Maor-Cahn R,Gueripel X,Ellingsgaard H,Schneider MK,Biollaz G,Fontana A,Reinecke M,Homo-Delarche F,Donath MY||Diabetes (56:2356)||2007|
Phenotypic variation in myocardial macrophage populations suggests a role for macrophage activation in SIV-associated cardiac disease.
MA5-11458 was used in immunohistochemistry to study the role of macrophage activation in SIV-associated cardiac disease
|Yearley JH,Pearson C,Shannon RP,Mansfield KG||AIDS research and human retroviruses (23:515)||2007|
Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis.
MA5-11458 was used in immunohistochemistry to investigate the mechanism for the increase of heme oxygenase expression in sepsis
|Schaer DJ,Schaer CA,Schoedon G,Imhof A,Kurrer MO||European journal of haematology (77:432)||2006|
CD163 antigen; hemoglobin scavenger receptor; macrophage-associated antigen; scavenger receptor cysteine-rich type 1 protein M130
CD163; M130; MM130; SCARI1