MA5-14140 targets L1 Cell Adhesion Molecule in immunohistochemistry (paraffin), immunoprecipitation, and Western blot applications and shows reactivity with human samples.
The MA5-14140 immunogen is homogenous suspension of 16 week human fetal brain.
MA5-14140 has been successfully used in immunohistochemistry analysis of NCAM1 in mouse E16.5 frozen lung sections.
The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: antigen identified by monoclonal antibody R1; CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; Neural cell adhesion molecule L1; SPG1
Gene Aliases: CAML1; CD171; HSAS; HSAS1; L1; L1CAM; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1
UniProt ID: (Human) P32004
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor