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| Applications | Tested Dilution | Publications |
|---|---|---|
Flow Cytometry (Flow) |
Assay-dependent | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Bovine |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
BAQ30A |
Immunogen |
Cells from multiple species |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Storage buffer |
tissue culture supernatant |
Contains |
0.09% sodium azide |
Storage conditions |
4° C, do not freeze |
RRID |
AB_2745264 |
Mouse anti Bovine CD18, clone BAQ30A, recognizes bovine CD18 also known as ITGB2 or integrin beta-2.
CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes. CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling. CD18 forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits, and these integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. Defects in the CD18 gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the CD18 protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD18; CD18 subunit; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; Integrin beta-2; integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); Leu-CAM receptor; leukocyte surface protein
Gene Aliases: CD18; ITGB2
UniProt ID: (Bovine) P32592
Entrez Gene ID: (Bovine) 281877
Molecular Function:
integrin
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