|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rat / IgG2a|
|Immunogen||mouse CD19 antigen|
|Storage buffer||PBS with sucrose, 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation. It is expressed in all B cell precursor leukemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The manganese superoxide dismutase mimetic, M40403, protects adult mice from lethal total body irradiation.
RM7704 was used in flow cytometry to report that a non-peptidyl mimetic of MnSOD reduces total body irradiation-induced tissue damage
|Thompson JS,Chu Y,Glass J,Tapp AA,Brown SA||Free radical research (44:529)||2010|
|Not Applicable||Not Cited||
Absence of IL-23p19 in donor allogeneic cells reduces mortality from acute GVHD.
RM7704 was used in flow cytometry to test if deficiency of p19 in the allogeneic donor transplant reduces the inflammation caused by acute GVHD
|Thompson JS,Chu Y,Glass JF,Brown SA||Bone marrow transplantation (45:712)||2010|