CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation. It is expressed in all B cell precursor leukemias.
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Protein Aliases: AW495831; B-lymphocyte antigen CD19; differentiation antigen CD19
Gene Aliases: AW495831
UniProt ID: (Mouse) P25918
Entrez Gene ID: (Mouse) 12478