|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Nalm 1 Human cell line|
|Storage buffer||PBS with 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.
CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation. It is expressed in all B cell precursor leukemias.
Class 2 Device
Preclinical evaluation of carcinoembryonic cell adhesion molecule (CEACAM) 6 as potential therapy target for pancreatic adenocarcinoma.
MHCD1904 was used in flow cytometry to investigate targeting CEACAM6 for treatment of pancreatic adenocarcinomas.
|Strickland LA,Ross J,Williams S,Ross S,Romero M,Spencer S,Erickson R,Sutcliffe J,Verbeke C,Polakis P,van Bruggen N,Koeppen H||The Journal of pathology (218:380)||2009|
Adiponectin, a fat cell product, influences the earliest lymphocyte precursors in bone marrow cultures by activation of the cyclooxygenase-prostaglandin pathway in stromal cells.
MHCD1904 was used in flow cytometry to test if adiponectin affects lymphohematopoiesis.
|Yokota T,Meka CS,Kouro T,Medina KL,Igarashi H,Takahashi M,Oritani K,Funahashi T,Tomiyama Y,Matsuzawa Y,Kincade PW||Journal of immunology (Baltimore, Md. : 1950) (171:5091)||2003|
Flow cytometry in the bone marrow staging of mature B-cell neoplasms.
MHCD1904 was used in flow cytometry to ask if flow cytometry can be used for the detection of bone marrow involvement in the different types of B-cell malignant neoplasms.
|Stacchini A,Demurtas A,Godio L,Martini G,Antinoro V,Palestro G||Cytometry. Part B, Clinical cytometry (54:10)||2003|
Investigation of human spleen dendritic cell phenotype and distribution reveals evidence of in vivo activation in a subset of organ donors.
MHCD1904 was used in flow cytometry to characterize human splenic dendritic cells.
|McIlroy D,Troadec C,Grassi F,Samri A,Barrou B,Autran B,Debré P,Feuillard J,Hosmalin A||Blood (97:3470)||2001|
Enhanced myeloid specificity of CD117 compared with CD13 and CD33.
MHCD1904 was used in flow cytometry to compare the expression pattern of CD13, CD33, and CD117 in patients with acute myelogenous leukemia.
|Nomdedéu JF,Mateu R,Altès A,Llorente A,Rio C,Estivill C,López O,Ubeda J,Rubiol E||Leukemia research (23:341)||1999|
Multilineage engraftment of refrozen cord blood hematopoietic progenitors in NOD/SCID mice.
MHCD1904 was used in flow cytometry assess the capacity of cord blood stem cells to repopulate irradiated NOD/SCID mice after cryopreservation
|Timeus F,Crescenzio N,Sanavio F,Fazio L,Doria A,Foglia L,Pignochino Y,Berger M,Piacibello W,Madon E,Cordero di Montezemolo L,Fagioli F||Haematologica (91:369)||2006|