|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Nalm 1 Human cell line|
|Storage buffer||PBS with 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The R-phycoerythrin (PE)-Cy7® tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a 488 nm laser without occupying traditional channels associated with FITC and PE. Alternatively, the PE dye tandem can be excited using a 532 nm or 561 nm laser.
CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation. It is expressed in all B cell precursor leukemias.
Analyte Specific Reagent
Evaluation and mechanistic analysis of the cytotoxicity of the acyl glucuronide of nonsteroidal anti-inflammatory drugs.
MHCD1912 was used in flow cytometry to investigate the cytotoxicity of acyl glucuronide.
|Miyashita T,Kimura K,Fukami T,Nakajima M,Yokoi T||Drug metabolism and disposition: the biological fate of chemicals (42:1)||2014|
Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin.
MHCD1912 was used in flow cytometry to investigate the trafficking patterns of leukocytes between the systemic circulation and the noninflamed central nervous system.
|Kivisäkk P,Mahad DJ,Callahan MK,Trebst C,Tucky B,Wei T,Wu L,Baekkevold ES,Lassmann H,Staugaitis SM,Campbell JJ,Ransohoff RM||Proceedings of the National Academy of Sciences of the United States of America (100:8389)||2003|