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|Tested species reactivity||Human|
|Published species reactivity||Non-human primate, Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Nalm 1 Human cell line|
|Storage buffer||PBS with 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Our Pacific Blue™ dye is optimally excited by the violet laser and conjugates of this dye are strongly fluorescent even at neutral pH. Pacific Blue™ and Pacific Orange™ dye conjugates can be simultaneously excited at 405 nm and emit at 455 nm and 551 nm, respectively, facilitating two-color analysis.
CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation. It is expressed in all B cell precursor leukemias.
Analyte Specific Reagent
Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells.
MHCD1928 was used in flow cytometry to test if mesenchymal stromal cells support the growth and survival of leukemic stem cells in vitro.
|Ito S,Barrett AJ,Dutra A,Pak E,Miner S,Keyvanfar K,Hensel NF,Rezvani K,Muranski P,Liu P,Melenhorst JJ,Larochelle A||Stem cell research (14:95)||2015|
Quantitative and qualitative differences in the T cell response to HIV in uninfected Ugandans exposed or unexposed to HIV-infected partners.
MHCD1928 was used in flow cytometry to characterize T cell responses of HIV-exposed, yet persistently uninfected individuals.
|Pala P,Serwanga J,Watera C,Ritchie AJ,Moodie Z,Wang M,Goonetilleke N,Birabwa E,Hughes P,Senkaali D,Nakiboneka R,Grosskurth H,Haynes B,McMichael A,Kaleebu P||Journal of virology (87:9053)||2013|
Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine.
MHCD1928 was used in flow cytometry to assess the response to the pandemic (p)HN vaccine in young and elderly individuals in vivo and in vitro.
|Frasca D,Diaz A,Romero M,Phillips M,Mendez NV,Landin AM,Blomberg BB||International immunology (24:175)||2012|
Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1.
MHCD1928 was used in flow cytometry to discuss the use of internal antigens to provide better protection against multiple influenza subtypes.
|Berthoud TK,Hamill M,Lillie PJ,Hwenda L,Collins KA,Ewer KJ,Milicic A,Poyntz HC,Lambe T,Fletcher HA,Hill AV,Gilbert SC||Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (52:1)||2011|
Enlarged memory T-cell pool and enhanced Th1-type responses in chronic myeloid leukemia patients who have successfully discontinued IFN-¿ monotherapy.
MHCD1928 was used in flow cytometry to examine the function of NK- and T-cells in order to understand how chronic myeloid leukemia patients maintain the treatment response after IFN-α discontinuation.
|Ilander M,Kreutzman A,Rohon P,Melo T,Faber E,Porkka K,Vakkila J,Mustjoki S||PloS one (9:null)||2014|
Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization.
MHCD1928 was used in flow cytometry to explore the multifunctional IL-17A responses against S. Typhi antigens in T memory subsets.
|McArthur MA,Sztein MB||PloS one (7:null)||2012|
Reduced T regulatory cell response during acute Plasmodium falciparum infection in Malian children co-infected with Schistosoma haematobium.
MHCD1928 was used in flow cytometry to discuss how co-infections and secondary parasite infections may disrupt the immunologic responses induced by a pre-existing parasitic infection.
|Lyke KE,Dabo A,Arama C,Daou M,Diarra I,Wang A,Plowe CV,Doumbo OK,Sztein MB||PloS one (7:null)||2012|
|Non-human primate||Not Cited||
Immune modulation through 4-1BB enhances SIV vaccine protection in non-human primates against SIVmac251 challenge.
MHCD1928 was used in flow cytometry to investigate the contribution of costimulatory molecules during SIV vaccination.
|Hirao LA,Hokey DA,Morrow MP,Jure-Kunkel MN,Weiner DB||PloS one (6:null)||2011|
Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.
MHCD1928 was used in flow cytometry to test if anti-CD8 Abs induce effector function.
|Clement M,Ladell K,Ekeruche-Makinde J,Miles JJ,Edwards ES,Dolton G,Williams T,Schauenburg AJ,Cole DK,Lauder SN,Gallimore AM,Godkin AJ,Burrows SR,Price DA,Sewell AK,Wooldridge L||Journal of immunology (Baltimore, Md. : 1950) (187:654)||2011|
AW495831; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; CD19; Differentiation antigen CD19; T-cell surface antigen Leu-12
B4; CD19; CVID3