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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Nalm 1 Human cell line|
|Conjugate||Alexa Fluor® 700|
|Storage buffer||PBS with 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 2 publications below|
The Alexa Fluor® 700 dye conjugate provides an excellent spectral match to the common long-wavelength excitation sources, with a high extinction coefficient.
CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation. It is expressed in all B cell precursor leukemias.
Analyte Specific Reagent
TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients.
MHCD1929 was used in flow cytometry to characterize therapy-induced T cell reactivity using a panel of 45 melanoma-associated CD8(+) T cell epitopes.
|Kvistborg P,Shu CJ,Heemskerk B,Fankhauser M,Thrue CA,Toebes M,van Rooij N,Linnemann C,van Buuren MM,Urbanus JH,Beltman JB,Thor Straten P,Li YF,Robbins PF,Besser MJ,Schachter J,Kenter GG,Dudley ME,Rosenberg SA,Haanen JB,Hadrup SR,Schumacher TN||Oncoimmunology (1:409)||2012|
Multiplexed immunophenotyping of human antigen-presenting cells in whole blood by polychromatic flow cytometry.
MHCD1929 was used in flow cytometry to describe protocols for immunostaining and multiparameter flow cytometric analysis of major human antigen-presenting cells in peripheral blood
|Fung E,Esposito L,Todd JA,Wicker LS||Nature protocols (5:357)||2010|
B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, T-cell surface antigen Leu-12, differentiation antigen CD19, AW495831