|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Full external domain of CD1a|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:15|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
MA5-14096 targets CD1a in IHC (P) applications and shows reactivity with Human samples.
The MA5-14096 immunogen is full external domain of CD1a.
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 is expressed on cortical thymocytes, Langerhans cells, and dendritic cells. It is absent on mature peripheral blood T cells but intracytoplasmic expression is detected on activated T lymphocytes. CD1 proteins have been demonstrated to restrict T-cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
High number of intraepithelial CD8+ tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer.
MA5-14096 was used in immunohistochemistry to study the correlaton between intraepithelial CD8+ tumor-infiltrating lymphocytes and the absence of lymph node metastases in patients with large early-stage cervical cancer
|Piersma SJ,Jordanova ES,van Poelgeest MI,Kwappenberg KM,van der Hulst JM,Drijfhout JW,Melief CJ,Kenter GG,Fleuren GJ,Offringa R,van der Burg SH||Cancer research (67:354)||2007|