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|Tested species reactivity||Mouse|
|Host / Isotype||Rat / IgG1, kappa|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1 µg/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
LFA-3 receptor, T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5, lymphocyte antigen 37, CD2 antigen, sheep red blood cell receptor, erythrocyte receptor, lymphocyte-function antigen-2, rosette receptor
Ly-37, LFA-2, Ly37
Protein metabolism and modification Protein modification Protein phosphorylation Phosphate metabolism Signal transduction Intracellular signaling cascade MAPKKK cascade Cell communication Cell adhesion-mediated signaling Ligand-mediated signaling Immunity and defense T-cell mediated immunity Cell adhesion