CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
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Protein Aliases: CD2 antigen (p50), sheep red blood cell receptor; erythrocyte receptor; LFA-3 receptor; lymphocyte-function antigen-2; rosette receptor; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5
Gene Aliases: LFA-2; RP4-655N15.2; SRBC; T11
UniProt ID: (Human) P06729
Entrez Gene ID: (Human) 914