MA1-90805 detects CD200 from rat samples.
CD200 is a type-1 membrane glycoprotein that contains two immunoglobulin domains, and belongs to the immunoglobulin superfamily. CD200 is a broadly distributed cell surface glycoprotein that interacts with a receptor on myeloid cells (CD200R) and is implicated in locally preventing macrophage activation. Distant, but recognizable, homologues of CD200 have been identified in many herpesviruses and poxviruses. Studies of the related genes in mouse and rat suggest that CD200 may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms of CD200 have been found. Diseases associated with CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy.
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Protein Aliases: Cd200 antigen; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2); MRC OX-2 antigen; OX-2 membrane glycoprotein
Gene Aliases: Cspmo2; Mox2; MRCOX2
Entrez Gene ID: (Rat) 24560