For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
CD200R (OX2R) is a receptor for the OX-2 membrane glycoprotein, and both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. CD200R is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. In mouse, CD200R is expressed primarily by peripheral blood monocytes and neutophils but also by other leucocytes including T-lymphocytes and mast cells. Further mouse studies of a gene related to CD200R suggests that the receptor may control myeloid function in a tissue-specific manner. Alternative splicing of CD200R results in multiple transcript variants. Diseases associated with CD200R dysfunction include primary hypertrophic osteoarthropathy.
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Protein Aliases: antigen identified by monoclonal antibody MRC OX-2 receptor; CD200 cell surface glycoprotein receptor; CD200 R1; Cell surface glycoprotein CD200 receptor 1; Cell surface glycoprotein OX2 receptor 1; OX102 antigen; OX2 receptor
Gene Aliases: Cd200r1; Mox2r; Ox2r
UniProt ID: (Rat) Q9ES58
Entrez Gene ID: (Rat) 64357
Molecular Function: transmembrane signal receptor