In Western blot, this product recognizes CD204 in J774 cells under non-reducing conditions only. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
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Protein Aliases: CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; Macrophage scavenger receptor types I and II; Scavenger receptor type A; SR-A; SR-AI/II
Gene Aliases: MRS-A; MSR; MSR-A; Msr1; Scara1; Scvr; SR-AI; SR-AII
UniProt ID: (Mouse) P30204