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|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Recombinant protein encoding the external domain of human CD22|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:2|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:20|
|Western Blot (WB)||1:100-1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 8 publications below|
MA5-11417 targets CD21 in WB, FACS and IHC (P) applications and shows reactivity with Human samples. This antibody is not suitable for Raji cell lysates or mouse BAF-3 cell lysates in Western blot analysis.
The MA5-11417 immunogen is recombinant protein encoding the external domain of human CD21.
CD21, also known as CR2, C3d receptor and EBV receptor), is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Epstein-Barr virus-associated adrenal smooth muscle tumors and disseminated diffuse large B-cell lymphoma in a child with common variable immunodeficiency: a case report and review of the literature.
MA5-11417 was used in immunohistochemistry to investigate the clinical and pathological features in a girl with common variable immunodeficiency
|Petrilli G,Lorenzi L,Paracchini R,Ubiali A,Schumacher RF,Cabassa P,Facchetti F||International journal of surgical pathology (22:712)||2014|
Occurrence of nodular lymphocyte-predominant hodgkin lymphoma in hermansky-pudlak type 2 syndrome is associated to natural killer and natural killer T cell defects.
MA5-11417 was used in immunohistochemistry to study factors associated with nodular lymphocyte-predominant hodgkin lymphoma in hermansky-pudlak type 2 syndrome
|Lorenzi L,Tabellini G,Vermi W,Moratto D,Porta F,Notarangelo LD,Patrizi O,Sozzani S,de Saint Basile G,Latour S,Pace D,Lonardi S,Facchetti F,Badolato R,Parolini S||PloS one (8:null)||2013|
CXCR5⁺ T helper cells mediate protective immunity against tuberculosis.
MA5-11417 was used in immunohistochemistry to study the role of CXCR5-positive T-cells in protective immunity against infection with Mycobacterium tuberculosis
|Slight SR,Rangel-Moreno J,Gopal R,Lin Y,Fallert Junecko BA,Mehra S,Selman M,Becerril-Villanueva E,Baquera-Heredia J,Pavon L,Kaushal D,Reinhart TA,Randall TD,Khader SA||The Journal of clinical investigation (123:712)||2013|
Folliculocentric B-cell-rich follicular dendritic cells sarcoma: a hitherto unreported morphological variant mimicking lymphoproliferative disorders.
MA5-11417 was used in immunohistochemistry to study three clinical cases of follicular dendritic cell sarcoma
|Lorenzi L,Lonardi S,Petrilli G,Tanda F,Bella M,Laurino L,Rossi G,Facchetti F||Human pathology (43:209)||2012|
The expression of IgM is helpful in the differentiation of primary cutaneous diffuse large B cell lymphoma and follicle center lymphoma.
MA5-11417 was used in immunohistochemistry to investigate the effect of IgM expressoin on the differentiation of primary cutaneous diffuse large B cell lymphoma and follicle center lymphoma
|Demirkesen C,Tüzüner N,Esen T,Lebe B,Ozkal S||Leukemia research (35:1269)||2011|
Copy number alterations and expression profiles of candidate genes in a pulmonary inflammatory myofibroblastic tumor.
MA5-11417 was used in immunohistochemistry to study the pathogenic mechanisms of pulmonary inflammatory myofibroblastic tumor
|Jung SH,Yim SH,Hu HJ,Jung CK,Lee SH,Kim DH,Chung YJ||Lung cancer (Amsterdam, Netherlands) (70:152)||2010|
Diagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases.
MA5-11417 was used in immunohistochemistry to investigate the diagnosis of lymphoid neoplasmas through bone marrow trephine biopsies
|Horváth E,Mezei T,Pávai Z,Turcu M,Demian S,Tóth E,Chira L,Jung I||Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (50:399)||2009|
Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma.
MA5-11417 was used in immunohistochemistry to study the production CXCL13 by follicular dendritic cells and its utility as a marker of follicular dendritic cell sarcoma
|Vermi W,Lonardi S,Bosisio D,Uguccioni M,Danelon G,Pileri S,Fletcher C,Sozzani S,Zorzi F,Arrigoni G,Doglioni C,Ponzoni M,Facchetti F||The Journal of pathology (216:356)||2008|
complement C3d receptor; complement component (3d/Epstein Barr virus) receptor 2; complement receptor type 2; EBV receptor; epstein-Barr virus receptor
C3DR; CD21; CR; CR2; CVID7; SLEB9